Skeletal effect of natural early menopause

Author

Caudarella R, Ceccoli L, Francucci CM, Rilli S, Boscaro M

Division of Endocrinology, Department of Internal Medicine, Polytechnic University of Marche, Ancona, Italy. cm.francucci@ospedaliriuniti.marche.it

Resource

J Endocrinol Invest 2010 ; 33(7 Suppl): 39-44.

Abstract

It is well-known that women with spontaneous or natural early menopause (NEM) (between ages of 40 and 45 yr) experience an increased risk of overall mortality, cardiovascular diseases, osteoporosis, neurological and/or psychiatric diseases, and other sequelae. On the contrary, the role of NEM is more contentious on the long-term bone consequences. The published data highlight that NEM has an ambiguous effect on bone mineral density, and is associated with an increased incidence of fractures, likely related to other risk factors rather than to osteoporosis. Therefore, an estrogen treatment should be considered for these women, especially if osteopenia is present at age of menopause.

Major Subject Heading(s)	Minor Subject Heading(s)
>Bone Density >Menopause, Premature [physiology] >Osteoporosis, Postmenopausal [etiology]	>Adult >Female >Humans >Menopause, Premature >Middle Aged >Osteoporosis, Postmenopausal >Osteoporotic Fractures [etiology] >Risk Factors

PMID: 20938225
Publication Type: Journal Article, Review
Citation Subset: IM
Last Modified:  : 2/20/2011

This article used the data from the U.S. National Library of Medicine (NLM), please read "Medline Legal Disclaimer" at http://www.woman-health.org/virtual/Medline_Legal_Disclaimer.