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February 5, 2012
Table of Contents

1 Introduction
[F] Gynecology / General Gynecology /
Choriocarcinoma

Wikipedia

  

DiseaseDisorder infobox |
Name = Choriocarcinoma |
ICD10 = (ICD-O 9100-9101) |
ICD9 = |

Choriocarcinoma is a malignant and aggressive cancer of the placenta. It is characterized by early hematogenous spread to the lungs.

Etiology/Epidemiology



It is preceded by
  • hydatidiform mole (50% of cases)

  • abortion of ectopic pregnancy (20% of cases)

  • normal term pregnancy (20-30% of cases)

Symptoms/Signs/Labs


  • increased human chorionic gonadotropin|β-hCG levels

  • vaginal bleeding

Pathology


On light microscopy, there is malignant trophoblastic proliferation without hydropic villi.

Treatment


Choriocarcinoma is one of the tumors that is most sensitive to chemotherapy. The cure rate, even for metastatic choriocarcinoma, is around 90-95%. Virtually everyone without metastases can be cured. Chemotherapy regimen include Methotrexate or dactinomycin.

Hysterectomy (surgical removal of the uterus) can also be offered to patients > 40 years of age or those desiring sterilization. It may be required for those with severe infection and uncontrolled bleeding.

med-stub

Category:Gynecology
Category:Oncology

Copyright & Resource Links
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Choriocarcinoma".


Last Modified:   2005-12-19


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