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May 22, 2012 |
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Protbox header |Name=Inhibin Protbox codes |Symbol=INHA |HGNCid=6065 |Chromosome=2 |Locus=q33-qter |AApro=--- |AltSymbols= |Codes=EntrezGene|3623, RefSeq|NM_002191, UniProt|P05111, OMIM|147380 |AApre=366 Protbox codes |Symbol=INHBA |HGNCid=6066 |Chromosome=7 |Locus=p15-p13 |AApro=--- |AltSymbols= |Codes=EntrezGene|3624, RefSeq|NM_002192, UniProt|P08476, OMIM|147290 |AApre=426 Protbox codes |Symbol=INHBB |HGNCid=6067 |Chromosome=2 |Locus=cen-q13 |AApro=--- |AltSymbols= |Codes=EntrezGene|3625, RefSeq|NM_002193, UniProt|P09529, OMIM|147390 |AApre=407 Protbox finish Inhibin is a peptide that is an inhibitor of FSH synthesis and secretion and participates in the regulation of the menstrual cycle. Inhibin contains an alpha and beta subunit linked by disulfide bonds. Two forms of inhibin differ in their beta subunits (A or B), while their alpha subunits are identical. Inhibin belongs to the Transforming growth factor|transforming growth factor-β (TGF-β) family. FSH stimulates the secretion of inhibin from the granulosa cells of the ovary. In turn, inhibin suppresses FSH. Inhibin secretion is diminished by GnRH, and enhanced by insulin-like growth factor-1 (IGF-1). Inhibin B reaches a peak in the early-mid menstrual cycle|follicular phase, and a second peak at ovulation, in contrast to inhibin A that reaches its peak in the mid-menstrual cycle|luteal phase. Inhibin is produced in the gonads, pituitary gland, placenta and other organs. Activin is a related peptide that counteracts inhibin. OMIM|147390 biology-stub Category:Reproductive system Category:Hormones of the ovary Category:Peptide hormones de:Inhibin fr:Inhibine This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Inhibin".
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