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July 30, 2010
Table of Contents
1 Introduction
Pre-eclampsia

Wikipedia

 

DiseaseDisorder infobox |
Name = Pre-eclampsia |
ICD10 = O11, O13, O14 |
ICD9 = 642.4-642.7 |

Pre-eclampsia (previously called toxemia) is a pregnancy-induced hypertension|hypertensive disorder of pregnancy. Pre-eclampsia is diagnosed when a pregnancy|pregnant woman develops high blood pressure (two separate readings taken at least 6 hours apart of 140/90 or more) and 300 mg of protein in a 24 hour urine sample (proteinuria). Swelling or edema(especially in the hands and face)was originally considered an important sign for a diagnoses of pre-eclampsia, but in current medical practice only hypertension and proteinuria are necessary for a diagnoses. Some women develop high blood pressure without the proteinuria, this is called Gestational Hypertension or, Pregnancy Induced Hypertension (PIH). Both Preeclampsia and PIH are very serious conditions and require careful monitoring of mother and baby.

Pre-eclampsia is much more common in the first pregnancy (3-5% of births) and usually becomes evident in the third trimester (and virtually always after the 20th week of pregnancy). It is also more common in women who have preexisting hypertension, diabetes,chronic renal failure|renal disease, and family history of pre-eclampsia. It is also more common in women with a multiple gestation (twins, triplets and more).

Pre-eclampsia may also occur in the immediate post-partum period or up to 6-8 weeks post-partum. This is referred to as "post partum pre-eclampsia".

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Pre-eclampsia is thought to be caused by inflammatory|inflammatory mediators secreted by the placenta and acting on the vascular endothelium. If severe, it progresses to fulminant pre-eclampsia, with headaches and visual disturbances, and further to HELLP syndrome and eclampsia. These are medical emergency|life-threatening conditions for both the developing fetus and the mother.

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There are many theories on the pathogenesis of preeclampsia. Most involve abnormal development of the placenta, which leads to a distressed placenta that secretes factors into the maternal blood. These factors damage the maternal blood vessels, leading to high blood pressure and protein in the urine.

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The most successful treatment for eclampsia or advancing preeclampsia is childbirth|delivery, either by induction (birth)|induction or Caesarean section. Some forms of preeclampsia can be treated with anti-hypertensive medication. In some cases women with eclampsia can be stabilized temporarily with magnesium sulfate intravenously to prevent seizures. Attempts will be made to delay delivery until the fetus has matured, but in severe cases where the mother's life is threatened, delivery must occur as soon as possible.

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  • Pregnancy-induced hypertension

  • Eclampsia

  • Hypomagnesemia


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  • http://www.emedicine.com/MED/topic633.htm Emedicine article on eclampsia


Category:Medical emergencies
Category:Obstetrics

de:Pr??eklampsie
fr:Pr??-??clampsie
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Pre-eclampsia".


Last Modified:   2005-12-23


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