Gynecology Sexual health

Tadalafil Wikipedia

Tadalafil Lilly ICOS LLC pyrazino1 ,2 :1,6pyrido3,4-bindole-1,4-dione, 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-, (6R,12aR)- C₂₂H₁₉N₃O₄ 389.41 Amides, Amines, Benzene, Ether, and Methyl

Image:Tadalafil.png|Tadalafil structure<br/>

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Tadalafil is a drug used to treat male erectile dysfunction (impotence). It was developed by the biotechnology firm ICOS and marketed worldwide by Eli Lilly and Company under the brand name Cialis. It works by inhibiting an enzyme known as CGMP specific phosphodiesterase type 5|PDE5. Due to its 36-hour effect it is also known as the "Weekend Pill". In the United States, tadalafil has Food and Drug Administration approval and became available in December, 2003.

The empirical formula for tadalafil is C₂₂H₁₉N₃O₄, and its official organic name is (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a- hexahydro-2-methyl-pyrazino1 ,2 :1,6pyrido3,4-bindole-1,4-dione. The molecular weight is 389.41. The tablets are yellow, film-coated, and almond-shaped, and are produced in 5, 10, or 20mg doses. A 20mg dose of Tadalafil is comparable to a 100mg dose of sildenafil (Viagra).

The most common Adverse effect (medicine)|side effects when using tadalafil are headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects usually go away after a few hours. Patients who get back pain and muscle aches usually get it 12 to 24 hours after taking the drug, and the symptom usually goes away after 48 hours.

In May 2005, the U.S. Food and Drug Administration found that tadalafil (along with other PDE5 inhibitors) could lead to vision impairment in certain patient groups, e.g. diabetics. An investigation is currently ongoing.

In the United States, Eli Lily has a multiyear agreement to promote tadalafil (Cialis) with professional golf's PGA TOUR.

• The word "specialist" is frequently caught by primitive spam email blockers because it contains the word "cialis."

• http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a604008.html NIH

Last Modified:   2005-12-19